Significance of PPD Test for the Relationship Between BCG Vaccine and COVID-19 in Patients on Kidney Transplant Waiting List.

BACKGROUND: The aim of this study was to determine the relationship between purified protein derivative of tuberculin (PPD) values, an indicator of BCG protection, and COVID-19 disease in patients with end-stage renal disease (ESRD) on the kidney transplant waiting list. METHODS: Age, sex, dialysis type, ERSD etiologies, and PPD values of patients on the renal transplant waiting list were recorded. SARS-CoV-2 PCR data, whether the patients were previously infected with the virus, and, if infected, the severity of the disease were noted. Data were statistically compared. RESULTS: PCR of 87 (47.02%) of 185 patients were studied; 107 of the patients were male and 78 were female, with a mean age of 52.8 years. The test result was positive for 28 patients. Of the patients for whom PCR was studied, 41 had a negative PPD result, while 46 had a positive PPD result. There was no correlation with SARS-CoV-2 PCR positivity in patients with a PPD ≤ 5 mm and > 5 mm. However, patients with pneumonic infiltration who required hospitalization had a significantly higher PPD value. CONCLUSIONS: The PPD measurement, which is an indicator of BCG protection, might be a significant parameter for predicting the course of the disease in SARS-CoV-2 pneumonia.

COVID-19 with a Fatal Outcome in a Kidney Transplant Recipient: Case Report

Coronavirus disease 2019 (COVID-19) has become a pandemic, with a mortality of up to 10% in the general population. Comorbidities such as diabetes and hypertension are common among the elderly. The clinical manifestations of viral pneumonia associated with COVID19 vary widely, from mild to severe, in patients who underwent solid organ transplantation, an immunosuppressed patient group. Further large-scale studies regarding the screening and treatment approaches for COVID-19 among patients undergoing transplantation are required. Herein, we report the case of a patient who underwent renal transplantation and developed the COVID-19 infection that resulted in mortality. (English) [ABSTRACT FROM AUTHOR] Koronavirüs hastalığı (COVID-19) günümüzde pandemik enfeksiyon olarak görülmekte ve genel popülasyonda mortalite oranı %3'lere ulaşmaktadır. Diyabet, hipertansiyon gibi eşlik eden komorbiditeler ve yaşlılarda daha fazla görülmektedir. Ímmünosüpresif hasta grubu olan solid organ tranplantı olan hastalarda COVID-19'a bağlı gelişen viral pnömoni seyri hafif seyirden ağır seyre geniş yelpaze göstermektdir. Nakil hastalarında COVID-19 tarama ve tedavi yaklaşımları titizlikle değerlendirilmeli, geniş serilerle dokümente edilmelidir. Biz bu olgu sunumunda böbrek nakli olmuş mortaliteyle sonuçlanan COVID-19 olgusunu sunmayı amaçladık. (Turkish) [ABSTRACT FROM AUTHOR] Copyright of Journal of Urological Surgery is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)